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Frequently Asked Questions About Rejuran

What is Rejuran and how does it work?

Rejuran (often called Rejuran Healer) is an injectable skin booster made from polynucleotides (PN) or polydeoxyribonucleotides (PDRN), which are DNA fragments derived from salmon. These DNA fragments are highly purified and biocompatible. They are designed to stimulate your skin’s natural healing and regeneration processes rather than simply “filling” lines like traditional dermal fillers.

In clinical research, PDRN has been shown to promote fibroblast activity and collagen synthesis, improve tissue repair, and enhance skin elasticity. By injecting Rejuran into the superficial to mid-dermis, it can help:

• Improve skin texture and fine lines
• Increase hydration and elasticity
• Support skin barrier repair
• Reduce the appearance of enlarged pores and mild acne scarring

What are the common treatment areas for Rejuran?

Because Rejuran is a skin rejuvenation treatment rather than a volumizing filler, it is typically used in areas where the skin is thin, delicate, or showing early to moderate signs of aging. Common treatment areas include:

• Full face (cheeks, temples, lower face) for overall texture and glow
• Under-eye area for crepiness and fine lines
• Forehead and glabella (between the brows) for fine lines and skin quality
• Neck for crepey, sun-damaged skin
• Décolletage (chest) for fine lines and sun damage
• Hands for improved texture and skin quality

Some practitioners also use Rejuran to support healing in acne-prone or scarred areas, as PDRN has been shown to aid skin regeneration and wound repair. Your provider will assess which areas are suitable based on your skin condition and goals.

What skin concerns can Rejuran help with?

Rejuran is primarily a skin quality and regeneration treatment. It may be recommended for:

• Fine lines and early wrinkles
• Dull, tired-looking skin
• Mild to moderate acne scarring and textural irregularities
• Enlarged pores
• Loss of elasticity or “crepey” skin
• Mild pigment irregularities and overall tone (as part of a broader plan)
• Skin that has been damaged by sun exposure or environmental stress

Studies on PDRN-based injectables have reported improvements in skin elasticity, hydration, and dermal thickness, which translate clinically into smoother, healthier-looking skin.

What happens during a Rejuran treatment session?

A typical Rejuran session involves:

1. Consultation and assessment – Your practitioner reviews your medical history, examines your skin, and discusses goals and expectations.
2. Cleansing and numbing – The skin is thoroughly cleansed, and a topical anesthetic cream is usually applied for comfort.
3. Microinjections – Using a fine needle or cannula, small amounts of Rejuran are injected into the superficial to mid-dermis in a series of tiny deposits (often in a grid-like pattern).
4. Post-treatment care – Mild redness or small bumps (injection “blebs”) are common immediately after and usually subside within 24–48 hours.

The procedure typically takes 30–60 minutes, depending on the areas treated. Most people can resume normal activities the same or next day, following aftercare instructions.

How many Rejuran sessions will I need and how long do results last?

Rejuran is usually performed as a series for best results. A common protocol is:

• Initial course: 3–4 sessions, spaced about 3–4 weeks apart
• Maintenance: 1 session every 6–12 months, depending on skin condition and aging process

Clinical data on PDRN-based skin treatments show gradual improvements in skin elasticity and texture over several weeks, as collagen remodeling and tissue repair take time. Many patients notice:

• Early improvements in hydration and radiance within 2–4 weeks
• More visible changes in texture, fine lines, and pore size after the second or third session
• Results that can last 6–12 months before a maintenance session is recommended

Individual longevity varies with age, lifestyle, sun exposure, and skincare routines.

Is Rejuran safe? What are the possible side effects?

Rejuran is generally well tolerated when administered by a properly trained medical professional. PDRN and PN-based injectables have been used in dermatology and wound healing with a good safety profile. However, as with any injectable procedure, side effects are possible. Common, usually mild and temporary effects include:

• Redness and pinpoint bleeding at injection sites
• Small raised bumps or swelling where product was placed
• Bruising
• Mild tenderness or itching

These effects typically resolve within a few days. Less common but more serious risks can include:

• Infection
• Allergic reaction
• Vascular compromise (if injected improperly)
• Nodules or unevenness

To minimize risk, ensure your treatment is performed in a medical setting with sterile technique, by a clinician trained in facial anatomy and injectable procedures. Always disclose allergies, medications (especially blood thinners), and medical conditions beforehand.

Who is a good candidate for Rejuran?

You may be a good candidate for Rejuran if:

• You have mild to moderate signs of aging (fine lines, early wrinkles, dullness)
• You want to improve skin quality rather than add volume
• You have textural concerns such as mild acne scarring or enlarged pores
• You prefer a gradual, natural-looking improvement
• You are willing to commit to a series of treatments

Rejuran may not be suitable if you are pregnant or breastfeeding, have active skin infections or severe inflammatory skin disease in the treatment area, have a known allergy to any component of the product, or have certain autoimmune or bleeding disorders. A qualified provider will review your medical history and determine suitability.

Who can administer Rejuran in New York?

Regulations vary by country and region, but Rejuran is a prescription-only injectable and should only be administered by licensed medical professionals. In New York, you should look for:

• Physicians – Board-certified dermatologists, plastic surgeons, cosmetic physicians, or other doctors with training in aesthetic injectables.
• Nurse practitioners / physician associates / registered nurses – Where local laws allow, these clinicians may perform injectable treatments under their own license or under the supervision or delegation of a physician, provided they have specific training in aesthetics and facial injectables.
• Regulatory requirements – Check your local health authority or medical board for rules on who can legally perform cosmetic injections in New York. Many jurisdictions require prescribers to conduct a face-to-face consultation before treatment and mandate appropriate training and competency in aesthetic procedures.

When choosing a provider in New York, verify:

• Medical license and board certification (where applicable)
• Specific training and experience with Rejuran or similar PN/PDRN skin boosters
• Before-and-after photos of their own patients
• That treatments are carried out in a registered medical clinic with proper infection control and emergency protocols

Avoid non-medical settings or unlicensed practitioners, as improper injection technique increases the risk of complications.

How much does Rejuran cost in New York?

The cost of Rejuran in New York varies based on:

• Number of syringes or vials used per session
• Number of sessions in your treatment plan
• Practitioner’s qualifications and experience
• Clinic location and overhead
• Whether Rejuran is combined with other treatments (e.g., lasers, microneedling, or neuromodulators)

Many clinics price Rejuran per syringe or per area, and a full initial course (3–4 sessions) is usually recommended. Because prices can vary significantly, it’s best to schedule a consultation in New York for a personalized quote. Cosmetic injectable treatments are typically considered elective and not covered by insurance.

How should I prepare for a Rejuran treatment and what is the aftercare?

Before your appointment:

• Avoid blood-thinning medications and supplements (like aspirin, ibuprofen, high-dose vitamin E, fish oil) for several days if your doctor approves, to reduce bruising.
• Avoid alcohol for 24 hours before treatment.
• Inform your provider of all medications, allergies, and medical conditions.
• Reschedule if you have an active skin infection, cold sore, or illness.

After your appointment:

• Expect mild redness, bumps, or bruising for a few days.
• Avoid makeup, intense exercise, saunas, and hot baths for 24 hours or as advised.
• Avoid direct sun exposure and use a broad-spectrum sunscreen of at least SPF 30, as recommended by organizations like the American Academy of Dermatology.
• Use gentle skincare; avoid acids, retinoids, and harsh scrubs for several days.

Follow your provider’s specific instructions, and contact the clinic promptly if you notice increasing pain, spreading redness, or any symptoms that concern you.

Sources

• Polynucleotides and PDRN in skin regeneration – Journal of Cosmetic and Laser Therapy (PubMed)
• PDRN for tissue repair and wound healing – International Journal of Molecular Sciences (PubMed)
• American Academy of Dermatology – Sun protection and skin care guidelines
• International Society of Aesthetic Plastic Surgery – Education and training standards in aesthetic medicine

Medically reviewed by Dr. David Martinez, April 30, 2024